Drug and Protein Stability

Drug screening is technical examination of hair, semen, sweat, oral, and semen samples for determining the absence or presence of specific drugs or the met…

Drug screening is technical examination of hair, semen, sweat, oral, and semen samples for determining the absence or presence of specific drugs or the metabolized traces.

Drug screening is turning out to be a significant safety issue at workplace for Human Resource and Safety professionals. Most of Fortune 500 corporations do drug screening. The main aim is lessening the impact of drug abuse from the workplace, which includes absenteeism, attitude problems, decreased productivity, theft, tardiness, turnover, violence and crime.

The Department of Labor of the United States of America estimates that usage of drug in workplace costs the employers billion of dollars each year in accidents, lost time, workers compensation costs, and health care.

Drug delivery is a process or method for dispensing any pharmaceutical compound for achieving the remedial effect in human beings or animals. These technologies are copyright protected formulation scientific technologies that alter drug release profile, assimilation, distribution and excretion for improving the efficacy and safety of products and compliance and convenience of patients.

The common drug delivery methods include preferred noninvasive peroral (via mouth), transmucosal (vaginal, sublingual/ buccal, nasal, rectal, and ocular) or inhalation routes. Several medications including antibody, protein and peptide, gene and vaccine based drugs are not delivered by making use of these routes. This is because they may be vulnerable to enzymatic dilapidation and will not be assimilated into systemic circulation effectively because of the charge issues and molecular size to be medically effective.

Protein Stability:

It is quantitatively depicted by the customary Gibbs energy change that is postulate in stretching the exceptional 3 dimensional construction to arbitrarily coiled polypeptide strands. Nevertheless, for constructing of fresh proteins or for improving the accessible protein stability, knowledge on overall Gibbs energy change is insufficient.