Adverse effects are associated with excessive intake. The early stage of toxicity includes the following: weakness, headache, somnolence, nausea, vomiting,…
Common side effects of Calcitriol :
Adverse effects are associated with excessive intake. The early stage of toxicity includes the following: weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, muscle pain, bone pain, metallic taste. The late stage symptoms of toxicity include the following: cardiac arrhythmias, hypertension, pruritus, conjunctivitis (calcific), anorexia, weight loss, pancreatitis, polyuria, polydipsia, nocturia, elevated BUN, nephrocalcinosis, hypercholesterolemia, elevated AST/ALT, albuminia, decreased libido, hyperthermia, photophobia, rhinorrhea, ectopic calcification, overt psychosis, dystrophy, sensory disturbances, dehydration, apathy, arrested growth, UTI.
Calcitriol Precautions :-
Tell your doctor if you have: heart disease, kidney disease or kidney stones, coronary artery disease (hardening of the arteries). This drug should be used only if clearly needed during pregnancy. It is not known if this medication appears in breast milk; consult your doctor before breast-feeding.
DRUG INTERACTIONS: Tell your doctor of any over-the-counter or prescription medication you may take including: digoxin, cholestyramine, colestipol, mineral oil, thiazide diuretics (water pills), phenobarbital, phenytoin, steroids. Do not start or stop any medicine without doctor or pharmacist approval.
OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include weakness, headache, loss of appetite, nausea, vomiting, stomach cramps, dizziness, and ringing in the ears.
NOTES: Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. Discuss this with your doctor.
MISSED DOSE: Take the missed dose as soon as you remember; do not take if it is almost time for the next dose. Instead, skip the missed dose and resume your usual dosing schedule. Do not “double-up” the dose to catch up.
STORAGE: Store at room temperature away from sunlight and moisture.
Used to treat vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hyperparathyroidism, and in the management of hypocalcaemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis.
Precaution and Warning while taking Calcitriol
The precaution and warnings of Calcitriol drug is as follows:
•Instruct patient to carefully follow the diet and calcium supplementation instructions supplied by health care provider.
•Advise patient to take prescribed dose without regard to meals but to take with food if GI upset occurs.
•Advise patient or caregiver using oral solution to use disposable graduated oral dispensers supplied with medication.
•Instruct dialysis patient to avoid using any magnesium-containing products (eg, antacids).
•Educate patient regarding signs and symptoms of hypercalcemia. Instruct patient to immediately inform health care provider if they occur.
•Advise women to notify health care provider if pregnant, planning to become pregnant, or breastfeeding.